Prevalence of Plasmodium Falciparum Anti-malarial Polymorphisms in Tanzania

A report of the chloroquine and amodiaquine resistance pfcrt-SVMNT haplotype in Tanzania raises concern about high-level resistance to the artesunate-amodiaquine combination treatment widely employed in Africa. Mutations in the pfmdr1 multi-drug resistance gene may also be associated with resistance, and a highly polymorphic microsatellite (ms-4760) of the pfnhe1 gene involved in quinine susceptibility has not been surveyed in Tanzania.

Leave a Reply

Your email address will not be published. Required fields are marked *

Thanks for submitting your comment!